High Intensity Interval Training for People With Stroke Deficits "HIIT-Stroke"

Recruiting

Phase N/A Results N/A

Trial Description

The purpose of this study is to compare the effects of an exercise training strategy called high-intensity interval training (HIIT) to moderate intensity continuous exercise (MICE), on walking function and cardiovascular fitness in stroke patients. Hypothesis: HIIT will result in significantly greater benefit to fitness and mobility than MICE.

Detailed Description

Using a randomized design, the study will evaluate the effects of 3 HIT sessions combined with 2 MICE sessions per week on cardiovascular fitness and mobility compared to MICE training 5 days/week. Participants post-stroke will be randomly assigned to either MICE (5 days per week (d∙wk-1)) or combined HIIT (3 d∙wk-1) with MICE (2 d∙wk-1). Both groups will be exercising 5 times per week (walking on a treadmill with harness for fall protection); 3 times at the centre and 2 times at home. Outcome measures will be conducted before and after 24 weeks of training.

Conditions

Interventions

  • High intensity interval training Behavioral
    Other Names: HIIT
    Intervention Desc: Supervised HIIT sessions will be conducted on a treadmill at Toronto Rehab's Cardiac Rehabilitation and Secondary Prevention Program. During each of the three supervised HIIT sessions each week, subjects will be prescribed 2 protocols with a combination of short to moderate duration exercise of near maximal intensity alternating longer periods of active recovery. The total duration for each HIT session will be approximately 20 minutes with an additional 5 minutes warm-up and cool down period.
    ARM 1: Kind: Experimental
    Label: High Intensity Training
    Description: High Intensity Interval Training patients will attend the centre 3 times/week for 24 weeks. All subjects will participate in MICE aerobic training 5 days/week in the first four weeks of the study to provide a foundation of fitness and endurance for the safe prescription of HIIT. Subsequently, the HIIT group will replace 3 MICE training days with 3 HIIT. HIIT sessions will include two 20 minute protocols; 30:60 second work:active rest ratio, and 120:180 second work:active rest ratio on a treadmill with a harness for fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community, which has been shown to be both safe and effective
  • Moderate Intensity Continuous Exercise Behavioral
    Other Names: MICE; Standard
    Intervention Desc: MICE sessions represent the standard of care exercise prescription at TRI. Participants will be instructed to complete 20-60 minutes of continuous aerobic exercise at or around the ventilatory anaerobic threshold achieved on the cardiopulmonary exercise test.
    ARM 1: Kind: Experimental
    Label: Moderate Intensity Exercise
    Description: Moderate Intensity Continuous Exercise patients will attend the centre 3 times/week for 24 weeks. Participants will be progressed to 30 to 60 minutes of continuous exercise at the heart rate that occurred at the anaerobic threshold on the exercise test. Participants will exercise on a treadmill with a harness ofr fall protection. In addition to supervised exercise training (3 times/week), MICE will be conducted 2 times/week in the home/community by both cohorts.

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in Cardiovascular fitness - Peak oxygen uptake (VO2peak) 0, 24 weeks
Primary Change in Six Minute Walk Test 0, 24 weeks
Secondary Neuropsychological Test Battery (change over time) 0, 24 weeks
Secondary VO2 during HIT and MICE 9 weeks and 24 weeks
Secondary Change in Dual task gait velocity 0, 24 weeks
Secondary Adherence 0 to 24 weeks
Secondary Adverse Events 0 to 24 weeks
Secondary Patient satisfaction 24 weeks

Sponsors