Hemiparetic Arm Robotic Mobilization With Non Invasive Electrical Stimulation "hARMonies"

Enrolling by invitation

Phase N/A Results N/A



  • Chollet F, DiPiero V, Wise RJ, Brooks DJ, Dolan RJ, Frackowiak RS. The functional anatomy of motor recovery after stroke in humans: a study with positron emission tomography. Ann Neurol. 1991 Jan;29(1):63-71. Pubmed ID:1996881
  • Cicinelli P, Traversa R, Rossini PM. Post-stroke reorganization of brain motor output to the hand: a 2-4 month follow-up with focal magnetic transcranial stimulation. Electroencephalogr Clin Neurophysiol. 1997 Dec;105(6):438-50. Pubmed ID:9448645
  • Kinsbourne, M. (1974). Mechanisms of hemispheric interaction in man. In Hemispheric Disconnection and Cerebral Function, M. Kinsbourne, and W. Smith, eds. (Springfield: Charles C Thomas).
  • Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, Kwong KK, Kennedy DN, Finklestein SP, Rosen BR. A functional MRI study of subjects recovered from hemiparetic stroke. Stroke. 1997 Dec;28(12):2518-27. Pubmed ID:9412643
  • Cunningham DA, Machado A, Janini D, Varnerin N, Bonnett C, Yue G, Jones S, Lowe M, Beall E, Sakaie K, Plow EB. Assessment of inter-hemispheric imbalance using imaging and noninvasive brain stimulation in patients with chronic stroke. Arch Phys Med Rehabil. 2015 Apr;96(4 Suppl):S94-103. doi: 10.1016/j.apmr.2014.07.419. Pubmed ID:25194451
  • Delvaux V, Alagona G, Gérard P, De Pasqua V, Pennisi G, de Noordhout AM. Post-stroke reorganization of hand motor area: a 1-year prospective follow-up with focal transcranial magnetic stimulation. Clin Neurophysiol. 2003 Jul;114(7):1217-25. Pubmed ID:12842718
  • Di Lazzaro V, Pilato F, Dileone M, Profice P, Capone F, Ranieri F, Musumeci G, Cianfoni A, Pasqualetti P, Tonali PA. Modulating cortical excitability in acute stroke: a repetitive TMS study. Clin Neurophysiol. 2008 Mar;119(3):715-23. doi: 10.1016/j.clinph.2007.11.049. Epub 2007 Dec 31. Pubmed ID:18165149
  • Di Pino G, Pellegrino G, Assenza G, Capone F, Ferreri F, Formica D, Ranieri F, Tombini M, Ziemann U, Rothwell JC, Di Lazzaro V. Modulation of brain plasticity in stroke: a novel model for neurorehabilitation. Nat Rev Neurol. 2014 Oct;10(10):597-608. doi: 10.1038/nrneurol.2014.162. Review. Pubmed ID:25201238
  • Duque J, Hummel F, Celnik P, Murase N, Mazzocchio R, Cohen LG. Transcallosal inhibition in chronic subcortical stroke. Neuroimage. 2005 Dec;28(4):940-6. Pubmed ID:16084737
  • Gerloff C, Bushara K, Sailer A, Wassermann EM, Chen R, Matsuoka T, Waldvogel D, Wittenberg GF, Ishii K, Cohen LG, Hallett M. Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke. Brain. 2006 Mar;129(Pt 3):791-808. Epub 2005 Dec 19. Pubmed ID:16364955
  • Grefkes C, Fink GR. Connectivity-based approaches in stroke and recovery of function. Lancet Neurol. 2014 Feb;13(2):206-16. doi: 10.1016/S1474-4422(13)70264-3. Review. Pubmed ID:24457190
  • Hummel FC, Cohen LG. Non-invasive brain stimulation: a new strategy to improve neurorehabilitation after stroke? Lancet Neurol. 2006 Aug;5(8):708-12. Review. Pubmed ID:16857577
  • Jang SH, Kwon HG. Change of the anterior corticospinal tract on the normal side of the brain in chronic stroke patients: Diffusion tensor imaging study. Somatosens Mot Res. 2015;32(1):25-30. doi: 10.3109/08990220.2014.949006. Pubmed ID:25166214
  • Jang SH, Kim K, Kim SH, Son SM, Jang WH, Kwon HG. The relation between motor function of stroke patients and diffusion tensor imaging findings for the corticospinal tract. Neurosci Lett. 2014 Jun 20;572:1-6. doi: 10.1016/j.neulet.2014.04.044. Pubmed ID:24796808
  • Kang N, Summers JJ, Cauraugh JH. Transcranial direct current stimulation facilitates motor learning post-stroke: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2016 Apr;87(4):345-55. doi: 10.1136/jnnp-2015-311242. Review. Pubmed ID:26319437
  • Klamroth-Marganska V, Blanco J, Campen K, Curt A, Dietz V, Ettlin T, Felder M, Fellinghauer B, Guidali M, Kollmar A, Luft A, Nef T, Schuster-Amft C, Stahel W, Riener R. Three-dimensional, task-specific robot therapy of the arm after stroke: a multicentre, parallel-group randomised trial. Lancet Neurol. 2014 Feb;13(2):159-66. doi: 10.1016/S1474-4422(13)70305-3. Epub 2013 Dec 30. Pubmed ID:24382580
  • Liebetanz D, Nitsche MA, Tergau F, Paulus W. Pharmacological approach to the mechanisms of transcranial DC-stimulation-induced after-effects of human motor cortex excitability. Brain. 2002 Oct;125(Pt 10):2238-47. Pubmed ID:12244081
  • Liepert J, Bauder H, Wolfgang HR, Miltner WH, Taub E, Weiller C. Treatment-induced cortical reorganization after stroke in humans. Stroke. 2000 Jun;31(6):1210-6. Pubmed ID:10835434
  • Maraka S, Jiang Q, Jafari-Khouzani K, Li L, Malik S, Hamidian H, Zhang T, Lu M, Soltanian-Zadeh H, Chopp M, Mitsias PD. Degree of corticospinal tract damage correlates with motor function after stroke. Ann Clin Transl Neurol. 2014 Nov;1(11):891-9. doi: 10.1002/acn3.132. Pubmed ID:25540803
  • Murase N, Duque J, Mazzocchio R, Cohen LG. Influence of interhemispheric interactions on motor function in chronic stroke. Ann Neurol. 2004 Mar;55(3):400-9. Pubmed ID:14991818
  • Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J Physiol. 2000 Sep 15;527 Pt 3:633-9. Pubmed ID:10990547
  • Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulation in humans. Neurology. 2001 Nov 27;57(10):1899-901. Pubmed ID:11723286
  • Nitsche MA, Nitsche MS, Klein CC, Tergau F, Rothwell JC, Paulus W. Level of action of cathodal DC polarisation induced inhibition of the human motor cortex. Clin Neurophysiol. 2003 Apr;114(4):600-4. Pubmed ID:12686268
  • Prange GB, Jannink MJ, Groothuis-Oudshoorn CG, Hermens HJ, Ijzerman MJ. Systematic review of the effect of robot-aided therapy on recovery of the hemiparetic arm after stroke. J Rehabil Res Dev. 2006 Mar-Apr;43(2):171-84. Review. Pubmed ID:16847784
  • Ranieri F, Podda MV, Riccardi E, Frisullo G, Dileone M, Profice P, Pilato F, Di Lazzaro V, Grassi C. Modulation of LTP at rat hippocampal CA3-CA1 synapses by direct current stimulation. J Neurophysiol. 2012 Apr;107(7):1868-80. doi: 10.1152/jn.00319.2011. Pubmed ID:22236710
  • Rosso C, Valabregue R, Attal Y, Vargas P, Gaudron M, Baronnet F, Bertasi E, Humbert F, Peskine A, Perlbarg V, Benali H, Lehéricy S, Samson Y. Contribution of corticospinal tract and functional connectivity in hand motor impairment after stroke. PLoS One. 2013 Sep 27;8(9):e73164. doi: 10.1371/journal.pone.0073164. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/1f472957-84b4-4251-9abb-3430469b14dd. Pubmed ID:24086272
  • Schulz R, Braass H, Liuzzi G, Hoerniss V, Lechner P, Gerloff C, Hummel FC. White matter integrity of premotor-motor connections is associated with motor output in chronic stroke patients. Neuroimage Clin. 2014 Nov 18;7:82-6. doi: 10.1016/j.nicl.2014.11.006. Pubmed ID:25610769
  • Schulz R, Frey BM, Koch P, Zimerman M, Bönstrup M, Feldheim J, Timmermann JE, Schön G, Cheng B, Thomalla G, Gerloff C, Hummel FC. Cortico-Cerebellar Structural Connectivity Is Related to Residual Motor Output in Chronic Stroke. Cereb Cortex. 2015 Oct 27. pii: bhv251. [Epub ahead of print] Pubmed ID:26508336
  • Schulz R, Koch P, Zimerman M, Wessel M, Bönstrup M, Thomalla G, Cheng B, Gerloff C, Hummel FC. Parietofrontal motor pathways and their association with motor function after stroke. Brain. 2015 Jul;138(Pt 7):1949-60. doi: 10.1093/brain/awv100. Pubmed ID:25935722
  • Thiel A, Vahdat S. Structural and resting-state brain connectivity of motor networks after stroke. Stroke. 2015 Jan;46(1):296-301. doi: 10.1161/STROKEAHA.114.006307. Review. Pubmed ID:25477218
  • Traversa R, Cicinelli P, Pasqualetti P, Filippi M, Rossini PM. Follow-up of interhemispheric differences of motor evoked potentials from the 'affected' and 'unaffected' hemispheres in human stroke. Brain Res. 1998 Aug 24;803(1-2):1-8. Pubmed ID:9729235
  • Wang LE, Tittgemeyer M, Imperati D, Diekhoff S, Ameli M, Fink GR, Grefkes C. Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study. Hum Brain Mapp. 2012 Dec;33(12):2941-56. doi: 10.1002/hbm.21417. Pubmed ID:22020952
  • Ward NS, Cohen LG. Mechanisms underlying recovery of motor function after stroke. Arch Neurol. 2004 Dec;61(12):1844-8. Review. Pubmed ID:15596603
  • Weiller C, Ramsay SC, Wise RJ, Friston KJ, Frackowiak RS. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol. 1993 Feb;33(2):181-9. Pubmed ID:8434880
  • Yang M, Yang YR, Li HJ, Lu XS, Shi YM, Liu B, Chen HJ, Teng GJ, Chen R, Herskovits EH. Combining diffusion tensor imaging and gray matter volumetry to investigate motor functioning in chronic stroke. PLoS One. 2015 May 12;10(5):e0125038. doi: 10.1371/journal.pone.0125038. Pubmed ID:25965398
  • Zheng X, Schlaug G. Structural white matter changes in descending motor tracts correlate with improvements in motor impairment after undergoing a treatment course of tDCS and physical therapy. Front Hum Neurosci. 2015 Apr 30;9:229. doi: 10.3389/fnhum.2015.00229. Pubmed ID:25983684

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