Glycerol and Dextran Combined in the Therapy of Acute Stroke

Completed

Phase N/A Results

Trial Description

To study the effect of glycerol therapy and a combination therapy of glycerol and dextran.

Interventions

  • Glycerol Drug
  • Dextran Drug
    Intervention Desc: Dextran is used as a volume expander.

Trial Design

Prospective, double-blind, randomized, placebo-controlled study involving 62 patients at a single hospital.

Patient Involvement

Patients were randomly assigned to 1 of 3 treatment regimens: 1) (GLY) glycerol 10% 500 ml over 4 hours I.V. followed by placebo (glucose 2.5% + sodium chloride 0.45%) 500 ml over 4 hours 2) (GLY + RHEO) glycerol 10% 500 ml over 4 hours I.V. followed by dextran 50 g and dextrose 25 g (Rheomacrodex) 500 ml over 3 hours I.V. 3) (PL) placebo 500 ml over 3 hours I.V.

Outcomes

Type Measure Time Frame Safety Issue
Primary Difference between neurologic examination according to a modified Mathew score at entry and after 6 weeks.