GLP-1's Effect on Cardiac Parameters and Mesenteric Blood Flow

Recruiting

Phase N/A Results N/A

Trial Description

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters

Detailed Description

to investigate the effect of the human incretin hormone GLP-1 on mesenteric blood flow and cardiac parameters, in healthy subjects, 4 arms, task force monitor

Conditions

Interventions

  • Saline Drug
    Other Names: Sodium Chloride
    ARM 1: Kind: Experimental
    Label: isotonic saline
    Description: 2 ml of isotonic saline, sc injection
  • 1,5 nmol/kg,GLP-1 sc injection Other
    Other Names: native GLP-1
    ARM 1: Kind: Experimental
    Label: GLP-1 9-36amide
    Description: 1,5 nmol/kg GLP-1 9-36amide, sc injection
    ARM 2: Kind: Experimental
    Label: Exendin-4
    Description: Exendin-4 ;10 ug,sc injection
    ARM 3: Kind: Experimental
    Label: isotonic saline
    Description: 2 ml of isotonic saline, sc injection
  • 1,5 nmol/kg GLP-1 9-36amide, sc injection Other
    Other Names: 1,5 nmol/kg GLP-1 9-36amide, sc injection
    ARM 1: Kind: Experimental
    Label: GLP-1
    Description: 1,5 nmol/kg,GLP-1 sc injection
    ARM 2: Kind: Experimental
    Label: Exendin-4
    Description: Exendin-4 ;10 ug,sc injection
    ARM 3: Kind: Experimental
    Label: isotonic saline
    Description: 2 ml of isotonic saline, sc injection
  • Exendin-4 ;10 ug,sc injection Other
    Other Names: Exendin-4 ;10 ug,sc injection
    ARM 1: Kind: Experimental
    Label: GLP-1
    Description: 1,5 nmol/kg,GLP-1 sc injection
    ARM 2: Kind: Experimental
    Label: GLP-1 9-36amide
    Description: 1,5 nmol/kg GLP-1 9-36amide, sc injection

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Outcomes Assessor)
  • Purpose: Basic Science
  • Endpoint: Pharmacodynamics Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary blood flow with in 120 minutes No

Sponsors