Ginkgo Diterpene Lactone Meglumine Injection on Platelet Reactivity in Acute Ischemic Stroke "GDPRS"

Not yet recruiting

Phase 2/3 Results N/A

Eligibility Criteria

Inclusion Criteria

1. Provision of informed consent;
2. Female or male with 18 years ≤age ≤ 80 years;
3. Within 72 hours symptom onset of ischemic stroke (diagnosis standard by the Chinese medical association of the fourth national conference on cerebrovascular disease);
4. Modified Rankin Scale Score ≤2 at the time of randomization;
5. NIHSS <12 points at the time of randomization;
6. Diagnosis of collaterals abstraction by phlegm and blood stasis in Traditional Chinese Medicine.

Exclusion Criteria

1. Diagnosis of infection, cancer, autoimmune diseases,severe renal or hepatic insufficiency or deep vein thrombosis,etc;
2. Current treatment (last dose given within 10 days before randomization) with anticoagulation therapy or anti-platelet therapy;
3. Presumed cardiac source of embolus, e.g., atrial fibrillation, known prosthetic cardiac valves, suspected endocarditis or other cardioembolic pathology for stroke;
4. Low or high platelet count (<100 x10^9/L or >300 x10^9/L);
5. Clear indication for anticoagulation or thrombolysis;
6. Head imaging studies have confirmed that, encephalitis, brain tumor, brain abscess and cause similar symptoms of disease, or confirm with hemorrhagic cerebral infarction, epidural hematoma, intracranial hematoma, intraventricular hemorrhage, subarachnoid hemorrhage, etc;
7. Blood pressure elevated(systolic > 220mmHg or diastolic >120mmHg);
8. Pregnancy or lactation, and women of childbearing age not practicing reliable contraception who do not have a documented negative pregnancy test;
9. Known allergic to acetylsalicylic acid or Ginkgo Diterpene Lactone Meglumine;
10. With hemorrhagic disease or have a bleeding tendency;
11. Clear indication for Dual Antiplatelet Therapy with acetylsalicylic acid and clopidogrel;
12. Have to be fed through a nasal feeding tube;
13. Contraindication to acetylsalicylic acid;
14. Presumed probably poor adherence, or any other inappropriate conditions for patients to participate in this study.