Gait Training and Brain Changes in Stroke Patients

Completed

Phase N/A Results N/A

Eligibility Criteria

- INCLUSION CRITERIA:
Stroke Patients
May be eligible for this research study if they:
- qualified for participation in the NRH locomotor protocol
- are between 18 and 80 years old
- have not had any other strokes
- had a stroke more than 3 months ago
- had a stroke that affected one side of the brain
- are able to perform the tasks required in the study with the paretic or non-paretic foot
- are willing and able to give consent
Healthy Volunteers
May be eligible for the research study if they:
- are between 18 and 80 years old
- are able to perform the tasks required in the study
- are willing and able to give consent
- a normal physical and neurological examination
EXCLUSION CRITERIA:
Exclusion criteria for stroke patients:
Sub-acute stroke patients will be not be eligible for the study if they:
- are unable to perform the behavioral tasks with the non-paretic foot,
- have had more than one stroke,
- have a history of alcohol or drug abuse or severe language disturbances (aphasia)
- have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus,
- are pregnant. Since the effects of MRI and TMS on fetal development are unknown, women of childbearing age will have pregnancy test prior to the study and pregnant women will be excluded.
- have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium, with the exception or dental braces in the mouth.
- simultaneous participation in any other intervention protocol for stroke.
- have with serious cognitive deficits (defined as equivalent to a mini-mental state exam score (MMSE) of 23 or less)
Exclusion criteria for healthy volunteers:
Healthy volunteers will not be eligible for the study if they:
- are unable to perform the tasks,
- have a history of alcohol or drug abuse or severe language disturbances or serious cognitive deficits,
- have uncontrolled medical problems, such as heart, lung or kidney disease, epilepsy or diabetes mellitus,
- are pregnant. Since the effects of MRI and TMS on fetal development are unknown, women of childbearing age will have pregnancy test prior to the study and pregnant women will be excluded.
- have a cardiac pacemaker, intracardiac lines, implanted medication pumps, neural stimulators, metal in the cranium except in the mouth, dental braces.