Functional Neuroimage in Assessment of Post-stroke Aphasia

Recruiting

Phase N/A Results N/A

Trial Description

The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear. It is hypothesized that the rTMS was associated with increased synaptic connection and neural regeneration which can be evaluated via functional neuroimage and neurofiber imaging analysis. The effect of rTMS intervention was monitored by clinical testing and neuroimaging study.

Detailed Description

2-week rTMS modulation has been proved to produce substantial clinical benefit with sham-controlled study. This trial aimed to investigate the possible mechanism and make clinical correlation.

Conditions

Interventions

  • RTMS Device
    Intervention Desc: To test the efficacy of this specific setting.
    ARM 1: Kind: Experimental
    Label: 1 Hz rTMS, real
    Description: 1 Hz rTMS over unaffected hemisphere for 15 minutes
    ARM 2: Kind: Experimental
    Label: 1Hz rTMS, sham
    Description: 1Hz sham rTMS, over unaffected hemisphere for 15 minutes

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Concise Chinese Aphasia Test Before the rTMS intervention, at 2nd week, and 3rd month No
Secondary Functional MRI Before rTMS intervention, and at the day completing the rTMS treatment. No

Sponsors