The substantial efficacy and the possible mechanism of repetitive transcranial magnetic stimulation (rTMS) improving language recovery remained unclear. It is hypothesized that the rTMS was associated with increased synaptic connection and neural regeneration which can be evaluated via functional neuroimage and neurofiber imaging analysis. The effect of rTMS intervention was monitored by clinical testing and neuroimaging study.
2-week rTMS modulation has been proved to produce substantial clinical benefit with sham-controlled study. This trial aimed to investigate the possible mechanism and make clinical correlation.
- RTMS Device
Intervention Desc: To test the efficacy of this specific setting. ARM 1: Kind: Experimental Label: 1 Hz rTMS, real Description: 1 Hz rTMS over unaffected hemisphere for 15 minutes ARM 2: Kind: Experimental Label: 1Hz rTMS, sham Description: 1Hz sham rTMS, over unaffected hemisphere for 15 minutes
- Allocation: Randomized
- Masking: Double Blind (Subject, Caregiver, Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Concise Chinese Aphasia Test||Before the rTMS intervention, at 2nd week, and 3rd month||No|
|Secondary||Functional MRI||Before rTMS intervention, and at the day completing the rTMS treatment.||No|
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