fMRI Neurofeedback for Motor Rehabilitation

Recruiting

Phase N/A Results N/A

Eligibility Criteria

- INCLUSION/EXCLUSION CRITERIA:
Inclusion criteria for healthy volunteers:
- Age 18 to 80
- Have a normal neurological exam
- Have the capacity to give informed consent
Exclusion criteria for healthy volunteers:
- Pregnancy
- Any report on the MRI safety questionnaire that prevents them from safely undergoing an MRI scan (e.g., metal implants) as per MRI center questionnaire
- History of claustrophobia
- Inability to carry out the task during scanning.
- Any medical condition that would prevent them from lying flat for up to 2 hours
Inclusion criteria for all patients with hemiparesis after stroke (regardless of doing TMS or not):
- Aged 18 to 80
- Stroke onset greater than 3 months prior to participation in the study
- Hemiparesis due to stroke involving the upper extremity
- Have the capacity to give informed consent. If the investigator feels the volunteer s capacity to give informed consent is questionable, the NIH Human Subjects Protection Unit (HSPU) will be requested to determine the individual s ability to consent.
Exclusion criteria for patients with hemiparesis after stroke:
- Pregnancy
- Any report on the MRI safety questionnaire that prevents them from safely undergoing an MRI scan (e.g., metal implants) as per the MRI center questionnaire
- History of claustrophobia
- Inability to carry out the task during scanning.
- Any medical condition that would prevent them from lying flat for up to 2 hours
Given the heterogeneity of our population after stroke, we do not have a strong hypothesis about the effects of any specific medications on the experimental outcomes. Thus, medications are not listed as an exclusion criteria because they do not pose a concern.
Furthermore, to take advantage of the heterogeneity of the lesion location on the experimental outcomes, we will perform a post-hoc stratification by lesion location in this initial study with stroke patients. There is little data to support a specific hypothesis that lesion size/location will contribute to differences in the participant s ability to successfully perform the task (e.g., control his/her neural activity using rtfMRI neurofeedback). The one prior study using rtfMRI with individuals with stroke recruited two participants with internal capsule lesions only. Thus, in this study we will stratify participants by lesion location in posthoc analyses and use this resulting information to inform future protocols for stroke patients using rtfMRI neurofeedback.
Exclusion for TMS portion specifically:
- Have metal in the body, such as a cardiac pacemaker, brain stimulator, shrapnel, surgical metal, clips in the brain, cochlear implants, metal fragments in the eye
- Have epilepsy or history of seizures, or being on medication for epilepsy.