Fluoxetine on Motor Rehabilitation After Ischemic Stroke "FLAME"

Completed

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Men and women aged from 18 to 85
- No motor relapse from a previous stroke
- Inclusion from day 5 to day 10 after stroke
- Ischemic stroke with unilateral motor deficit
- Motor NIHSS ≥ 5 on the affected side of the body
- NIHSS < 20
- Fugl Meyer Motor Scale <55
- Modified Rankin Scale between 1 and 5
- Informed consent obtained from the subject or a member of his family

Exclusion Criteria

- Pregnant or breast-feeding woman
- Woman able to procreate without valid contraception
- Subject protected by law
- Concomitant disease with unfavourable prognosis within 1 year
- Drug addiction
- Allergy to fluoxetine
- Hepatic failure (TGO and TGP >2N)
- Permanent Renal failure (Creatinin >180micromol/l)
- Patients treated by tricyclic antidepressant, selective serotonin reuptake inhibitor, monoamine oxidase inhibitor (IMAO), and neuroleptics in the past month
- Depression requiring pharmacological treatment
- Previous stroke with motor relapse
- Fugl Meyer Motor Scale > 55
- Modified Rankin Scale = 0 or 6
- Patients needing carotid surgery within 3 months
- Aphasia preventing correct evaluation of motor and depression scales.