Fluoxetine for Visual Recovery After Ischemic Stroke "FLUORESCE"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- MRI-confirmed acute ischemic stroke resulting in an isolated homonymous visual field loss.

Exclusion Criteria

- Known hypersensitivity to fluoxetine or other selective serotonin reuptake inhibitors
- National Institutes of Health Stroke Scale score greater than 5
- Premorbid modified Rankin Scale score greater than 2
- Premorbid monocular or binocular visual field deficits
- Premorbid retinopathy or optic neuropathy
- Premorbid depression
- History of cognitive impairment, dementia, or neurodegenerative disorder
- History of seizure disorder
- History of mania or hypomania
- History of hyponatremia
- History of angle-closure glaucoma or elevated intraocular pressure
- Current alcohol abuse or impaired liver function
- Current use of an antidepressant medication
- Current use of a medication likely to have an adverse interaction with fluoxetine
- Current use of a medication likely to impair post-stroke recovery
- Contraindication to MRI
- Pregnancy or lactation
- Hemorrhagic transformation of the index stroke, resulting in mass effect
- Enrollment in another clinical trial at the time of the index stroke