Examining How Motor Rehabilitation Promotes Brain Reorganization Following Stroke, an MRI Study

Active, not recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Males or females 18 years of age and over
- Experienced a stroke resulting in mild to moderate hemiparesis (some residual motor function, e.g. able to pick up a washcloth placed flat on a table) at least 6 months prior to enrollment. Suggested active range of motion criteria for this level of impairment include: 45° shoulder abduction and flexion, 20° elbow extension, 20° wrist extension, and 10° extension of thumb and fingers.
- Preserved ability to comprehend and participate in basic elements of the therapy

Exclusion Criteria

- Concurrent participation in other experimental trials for treatment of motor dysfunction
- Having received botulinum toxin injection within the past 3 months
- Previous intensive rehabilitation in the chronic phase post-stroke
- Serious/uncontrolled medical problems (e.g., dementia, severe pain, end-stage or degenerative diseases)
- Kidney disease as evidenced by eGFR<60
- Anemia
- Sickle cell disease
- History of kidney transplant
- Other evidence/history of renal disease
- Pregnancy
- Implanted metallic parts of implanted electronic devices, including pacemakers, defibrillators, aneurism clip or implant medication pump that are MRI incompatible
- An implanted brain stimulator
- Permanent tattoo (e.g., eye liner) containing metallic coloring
- Claustrophobia precluding MRI