Evaluating Error Augmentation for Neurorehabilitation "VREA"

Completed

Phase N/A Results N/A

Trial Description

This is a sub-project of a larger NIDRR Grant. One promising form of robotic training that leverages the power of neuro-plasticity is error augmentation. In this paradigm the computer singles out and magnifies a stroke survivor's movement errors from a desired trajectory, thus forcing the subjects to strengthen their control. Using the VRROOM, a state-of-the-art system which uses haptics (robotic forces) and graphics (visual display) interfaces, a subject's desired trajectory can be determined and the movement errors can be amplified in real-time with dramatic results. This project evaluates a practical approach of error augmentation, using therapist-driven trajectories. The investigators intend to determine clinical efficacy of several types of therapist-assisted error augmentation on retraining the nervous system in functional activities. The investigators will test two experimental treatments in a crossover design. The investigators hypothesize that combined haptic and visual error augmentation will lead to the best functional recovery.

Conditions

Interventions

  • Error Augmentation Behavioral
    Intervention Desc: error augmentation for arm motor recovery in individuals with stroke
    ARM 1: Kind: Experimental
    Label: Error Augmentation-Control
    ARM 2: Kind: Experimental
    Label: Control-Error Augmentation

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Arm motor recovery scores on the Fugl-Meyer Change from baseline in Fugl-Meyer to 11 weeks (with assessment periods occurring at 2 weeks, 3 weeks, 4 weeks, 6 weeks, 7 weeks, and 11 weeks) No
Secondary Number of blocks transferred in Box and Blocks Test same as primary No
Secondary Time and Quality of movement scores on the Wolf Motor Function Test same as primary No
Secondary Time scores and Ability scores on the Assessment of Simple Functional Reach Test same as primary No
Secondary Quantity and Quality with Motor Activity Log same as primary but added for ARM 2 No

Sponsors