Evaluating Anodal tDCS Preceding Aphasia Therapy

Terminated

Phase 1/2 Results

Trial Description

The purpose of this study is to determine if non-invasive brain stimulation (transcranial direct current stimulation) delivered prior to language therapy will improve word-finding in individuals with aphasia who are 6 months or greater post-stroke.

Conditions

Interventions

  • Transcranial direct current stimulation Device
    Other Names: C-tDCS
    Intervention Desc: Soterix 1x1 anodal tDCS
    ARM 1: Kind: Experimental
    Label: tDCS stimulation followed by aphasia therapy
    Description: 20 min of anodal tDCS followed by computerized naming therapy
    ARM 2: Kind: Experimental
    Label: sham tDCS stimulation followed by aphasia therapy
    Description: 20 min of sham tDCS followed by computerized naming therapy
    ARM 3: Kind: Experimental
    Label: anodal tDCS, then sham tDCS
    Description: Participants received 1 single 20 min session of anodal tDCS + computerized naming therapy. Following a 1 week washout period, they received 1 single 20 min session of sham tDCS + computerized aphasia therapy. Sequence of stimulation conditions was randomized across participants.
    ARM 4: Kind: Experimental
    Label: sham tDCS, then anodal tDCS
    Description: Participants received 1 single 20 min session of sham tDCS + computerized naming therapy. Following a 1 week washout period, they received 1 single 20 min session of anodal tDCS + computerized aphasia therapy. Sequence of stimulation conditions was randomized across participants.

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change from baseline in picture-word matching accuracy of trained items 1 week No
Primary Change from baseline in picture-word matching accuracy of untrained items 1 week No
Secondary Western Aphasia Battery 6 weeks No
Primary Mean Change From Baseline in Picture-word Matching Accuracy at Discharge baseline, discharge

Sponsors