EVA3S: Endarterectomy Versus Angioplasty in Patients With Severe Symptomatic Carotid Stenosis


Phase 3 Results


30-day risk of stroke or mortality was significantly increased in the stenting group compared with the endarterectomy group (3.9% vs. 9.6%, respectively; P =.01). Stenting showed a significantly lower risk for cranial nerve injury (10.4% vs. 1.5%), and a beneficial trend for systemic complications (3.1% vs. 1.9%;) but a much higher risk for both major local complications (1.2% vs. 3.1%) and TIA (0.8% vs. 2.3%). The trial failed to prove noninferiority of carotid stenting compared with carotid endarterectomy.