European Carotid Surgery Trial "ECST"

Completed

Phase 3 Results

Trial Description

To assess the risks and benefits of carotid endarterectomy in patients with recently symptomatic carotid stenosis.

Interventions

  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.

Trial Design

Multicenter, randomized, controlled trial of 3024 patients at 97 centers.

Patient Involvement

1811 were patients randomized to surgery, 1213 control (surgery avoided as long as possible).

Outcomes

Type Measure Time Frame Safety Issue
Primary Major stroke or death over mean follow-up period of 6.1 years.

Sponsors

UK Medical Research Council, European Union Biomed 1, Univ. of Oxford, and others.