European / Australasian Stroke Prevention in Reversible Ischaemia Trial "ESPRIT"

Completed

Phase N/A Results

Results

Anticoagulants versus aspirin comparison of ESPRIT was prematurely ended because ESPRIT reported that the combination of aspirin and dipyridamole was more effective than aspirin alone. Primary outcome events arose in 173 (13%) patients on combination treatment and in 216 (16%) on aspirin alone. The hazard ratio (HR) for the primary outcome event comparing anticoagulants with the combination treatment of aspirin and dipyridamole was 1.31 (0.98-1.75), and the HR for ischaemic events was 0.73 (0.52-1.01) and for major bleeding complications 2.56 (1.48-4.43). However, patients on the combination of aspirin and dipyridamole discontinued trial medication more often than those on aspirin alone (470 vs 184), mainly because of headache.