European and Australian Cooperative Stroke Study II "ECASS-II"

Completed

Phase 3 Results

Eligibility Criteria

Inclusion Criteria

Acute ischemic stroke in the MCA territory, within 6 hrs of stroke onset. CT required prior to entry. Aged 18-80 years.

Exclusion Criteria

Signs of intracerebral hemorrhage or parenchymal hypoattenuation exceeding a third of the middle cerebral artery territory, brain swelling exceeding a third of the middle cerebral artery territory, subarachnoid hemorrhage, initial SSS>50-58, seizure during previous 6 months, hypertension at time of randomization, traumatic brain injury within previous 14 days, surgery on central nervous system within previous 3 months, hemorrhage of GI or urinary tract, current therapy with IV or subcutaneous heparin, known hereditary or acquired hemorrhagic diathesis, lactation, pregnancy or recent parturition, lack of medically approved means of contraception in women of childbearing age, abnormal blood glucose levels or platelet counts, participation in another trial of an investigational drug.