To assess the safety and efficacy of intravenous thrombolysis with alteplase within 6 hours of stroke onset.
- Tissue plasminogen activator (Activase®)Drug
Other Names: Alteplase; tPA Intervention Desc: Thrombolytic
Randomized, double-blind, controlled trial of 800 patients at 108 centers in Europe, Australia and New Zealand.
409 patients received IV rt-PA (0.9 mg/kg) and 391 received placebo.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Modified Rankin Scale at day 90.|
|Secondary||NIHSS total score, change to day 30, and combination of Barthel and Rankin scores at day 90.|