Escitalopram Treatment In Acute Stroke "ESTIAS"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

- First ever ischemic stroke
- Age 18 years or above
Exclusion Criteria
- Hemorrhagic stroke
- Dementia or other neurodegenerative disease
- Antidepressant treatment within 6 months of admission
- Acute need for antidepressant treatment
- Drug abuse or other conditions that may indicate noncompliant behavior
- Liver failure (increased liver enzyme levels up to or more than 2 times upper limit)
- Renal failure (GFR under 30)
- Hyponatremia (S-potassium below 130 mmol/l)
- Actively bleeding ulcer
- Fatal stroke or other severe co morbidity that markedly decreases expected life span
- Prolonged QT interval (QTc above 500 ms)
- Ongoing treatment with drugs known to prolong the QT interval