Enoxaparin vs heparin for prevention of deep-vein thrombosis in acute ischaemic stroke: a randomized, double-blind study.


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

Patients with acute ischemic stoke, defined as patients with acute onset of paralysis lasting for at least 24 hours and necessitating bedrest, and a CT scan that confirmed the diagnosis of an ischemic brain infarction.

Exclusion Criteria

Patients who were unconcious or immobolized before the onset of stroke, or had evidence of either haemorrhagic stroke or stroke thought to be cardio-embolic in origin. Those who had evidence or history of DVT, PE, myocardial infarction or recent neurosurgery (within the last 3 months); history of subarachnoid haemorrhage, gastrointestinal bleeding or active peptic ulceration, hypersensitivity to heparin, LMWH or radio-opaque contrast media, severe heart failure, uncontrolled arterial hypertension, or hepatic or renal impairment, malignant disease, endocarditis, haemorrhagic diathesis, current drug abuse or any clinical condition requiring anticoagulant or antiplatelet therapy. Also patients who were pregnant or lactating, who had abnormal blood clotting tests, who had received other investigational medication within the last 3 months, or in whom the studytreatment could not be started within 48 h of theonset of the qualifying stroke.