To compare the use of enoxaprin with unfractionated heparin (UFH)in terms of their efficacy, safety, and overall risk forthromboprophylaxis in patients with acute ischemicstroke.
- Enoxaparin (Lovenox®)Drug
Intervention Desc: Low-molecular-weight heparin.
- Heparin (acute stroke) Drug
Intervention Desc: Intravenous anticoagulant.
Multicenter, double-blind, randomized study.
Patients were randomized to treatment with either enoxaparin40 mg once daily followed by two placebo injectionsat 8-hourly intervals, or UFH 5000 IU three times daily.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Bilateral phlebography was used to detect DVT at day 10 +/- 2 (or the end of treatment) with diagnosis confirmed by independent blinded review.|
|Secondary||To evaluate the overall profile of the two thromboprophylactic regimens, the rates of treatment failure (based on both efficacy and safety criteria) were compared.|