Enhanced Diagnostics for Early Detection of Atrial Fibrillation "DETECT-AF"


Phase N/A Results N/A

Trial Description

Paroxysmal atrial fibrillation can only be diagnosed during episodes when the arrhythmia is present.
The investigators hypothesize that the activation of the atrial myocardium resulting in the p-wave of the ecg should display abnormalities in diseased atria which are vulnerable for AF.

Detailed Description

In the first part of this trial different diagnostic techniques to detect arrythmogenic substrates of atrial fibrillation will be tested. If suitable parameters can be identified, a follow up trial to identify patients at risk for AF will be conducted before a stroke happens.
Parameters tested are
1. Electrophysiological differences between patients with paroxysmal AF and no history of AF
2. "Vascular Stiffness" detected by an iPhone app
All patients will undergo a cardiogoniometrie and a pulse wave analysis with an iPhone. Each exam takes 5 minutes.



  • ECG Device
    Intervention Desc: Patients receive a 5 Minute ECG recording and have their pulse recorded by an iPhone.
    ARM 1: Kind: Experimental
    Label: Paroxysmal Af
    Description: No Intervention is planned. All patients receive a 5 Minute ECG and have their pulse recordes by an iPhone.

Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

All inhospital and outpatient patients of our Institution with known paroxysmal AF are screened for eligebility. Control Group is equally recruted from patients of our intitution matching the studygroup.


Type Measure Time Frame Safety Issue
Primary Beat to beat variation of the electrical activation vector of the atrium Once during the exam (baseline) - No further follow up planned No
Secondary Averaged slope of pressure-curve Once during exam (5min, baseline) - No further follow up planned No
Secondary Heart rate variability Once during exam (5min, baseline) - No further follow up planned No