Endovascular Magnesium Sampling in Acute Stroke

Terminated

Phase N/A Results N/A

Trial Description

This investigation will address the safety and feasibility of distal, intra-arterial sampling through endovascular access, in acute stroke patients. Levels of Magnesium will be measured in the region of infarct in patients who had been treated with intravenous Magnesium therapy following an acute stroke. This study attempts to address whether the traditional intravenous means of neuroprotectant administration achieves adequate concentration of the therapeutic agent in the area of diseased tissue.

Trial Stopped: FAST-Mag study finished

Conditions

Interventions

  • Endovascular sampling Other
    Intervention Desc: Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations: withdrawal of 3ml of blood from vasculature distal to the occlusive thrombus
    ARM 1: Kind: Experimental
    Label: Endovascular Sampling
    Description: Paired sampling from the distal arterial(endovascular catheter) and peripheral venous (femoral sheath) locations in acute stroke patients undergoing endovascular recanalization who received intravenous Magnesium Sulfate as a part of the FAST-MAG study

Trial Design

  • Masking: Open Label
  • Purpose: Diagnostic
  • Endpoint: Safety Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Magnesium concentration intra-procedure (at time of first pass of retrieval device) No
Secondary Sampling feasibility intra-procedural (at time of first pass of retrieval device) No
Secondary Safety post-operative day 1 Yes

Sponsors