The purpose of this study is to determine whether levels of circulating endothelial progenitor cells (cEPC) are increased in the acute phase of ischemic stroke.
Endothelial dysfunction is a key component of atherosclerosis which contributes to the development of cardio- and cerebrovascular diseases. However, endothelial dysfunction (ED) is not established as a risk factor for ischemic stroke.
As a novelty the proposed trial investigates the following variety of indirect markers of endothelial function in acute ischemic stroke:
circulating endothelial progenitor cells (EPC), endothelial microparticles (EMP), ENDOPAT (RH- PAT ratio) in two regards:
1. time after ischemic events (< 48h, Days 4-5, day 7 or at discharge)
2. etiological stroke subtypes
It is not known whether these parameters are changed after acute cerebral ischemia and could possibly serve as specific target for treatment.
- Observation: Cohort
- Perspective: Prospective
- Sampling: Non-Probability Sample
Patients with first-ever ischemic stroke transferred to our stroke unit
|Type||Measure||Time Frame||Safety Issue|
|Primary||Levels of cEPC||<48h, day 4-5, discharge or day 7||No|
|Secondary||Levels of EMP||<48h, day 4-5, day 7 or discharge||No|
|Secondary||ENDOPAT||<48h, day 4-5,day 7||No|
Biospecimen Retention:Samples Without DNA - whole blood, serum, PBMC, plasma