Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial "AGONIST"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Fulfillment of at least 2 systemic inflammatory response syndrome (SIRS) criteria
- Suspected infection
- Serum lactate ≥3mmol/L

Exclusion Criteria

- Age below 21 years
- Known pregnancy
- Prisoners
- Do-not-attempt resuscitation status
- Known severe aortic insufficiency or severe anatomic abnormalities of the thoracic aorta
- Primary diagnosis of trauma, burns, active seizures, acute cerebral vascular accident, acute coronary syndrome, status asthmaticus, major cardiac arrhythmias, active gastrointestinal haemorrhage, seizure or drug overdose
- Requirement for immediate surgery
- Inability to do PLR (e.g. ankylosis of hip joint, severe sciatica)
- Treating physician deems aggressive care unsuitable
- Those unable to give informed consent and unable to comply with study requirements