Eliminate Coronary Artery Disease "ECAD"

Recruiting

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Men 35-50 years of age
- Women 45 - 59 years of age (must be sterile or >2 years postmenopausal)
- LDL cholesterol greater than 1.8 mmol/L (70 mg/dL) based on testing performed within 1 year
- One risk factor for Coronary Heart Disease other than lipid abnormality:
- Obesity and hypertension [BP >140 mmHg systolic and waist circumference > 100 cm in men and >90 cm in women]
- family history of premature myocardial infarction [<60 years]
- South Asian ethnic history
- currently smoking

Exclusion Criteria

- Currently taking cholesterol lowering medication
- Qualify for cholesterol lowering medication based on current guidelines
- Significant renal dysfunction (creatinine clearance <30 ml/min)
- Significant hepatic dysfunction (AST/ALT >2.0 times upper limit of normal)
- Active malignancy
- Diabetes
- Progressive or terminal illness, or other condition in which subject is unlikely to survive the study period
- Known allergy, hypersensitivity (anaphylaxis) ar adverse reaction to any statin
- Participation in a clinical trial (except observational studies) within previous 30 days
- Received any investigation product within 30 days prior to participation in this clinical trial
- Previously enrolled in this clinical trial