eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients

Enrolling by invitation

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Primary care patients
- Age ≥ 50 years
- Current depressive disorder
- Elevated CVD risk

Exclusion Criteria

- History of clinical cardiovascular disease
- Presence of the following chronic disorders: HIV/AIDS, chronic kidney disease, systemic inflammatory disease, or past-year cancer
- History of bipolar disorder or psychosis
- Continuous (e.g., daily) treatment for a systemic inflammatory condition (e.g., rheumatoid arthritis, lupus, Crohn's disease, and ulcerative colitis) in the past 3 months. Nonsteroidal anti-inflammatory drug (NSAID) use is allowed, given its high prevalence in the target population.
- • Current use of anticoagulants (Aspirin and cholesterol and blood pressure medications are allowed)
- Acute risk of suicide
- Severe cognitive impairment
- Current pregnancy
- Ongoing depression treatment with a psychiatrist outside of the Eskenazi Health/Midtown system (ongoing depression treatment with a Eskenazi Health/Midtown psychiatrist is allowed, as we will be able to collaborate and coordinate depression care)