Efficacy of Whole Extract of Licorice in Neurological Improvement of Patients After Acute Ischemic Stroke

Completed

Phase 1/2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Symptoms of acute ischemic stroke
- ROSIER score higher than 2
- Confirmation of ischemic brain damage in CT scan

Exclusion Criteria

- Clinically relevant preexisting neurological deficit or previous CVA
- Primary intracerebral hemorrhage
- Coma (level of consciousness more than 2 in NIHSS scale).
- Negative swallow test
- Patients undergoing hemicraniectomy
- History of epilepsy
- Clinical seizure at onset of stroke
- Systolic BP is >160 mmHg, diastolic BP>110 at onset of stroke (if a rise in blood pressure occurred in the course of study it was controlled according to medical guidelines)
- Atrial fibrillation or other tachy/bradyarrythmias at time of allocation or in the middle of intervention
- Ejection Fraction less than 45%
- Potassium less than 4 mEq/dl at onset of stroke
- Malignancy or premalignant state within 5 years
- Myocardial infarction in previous month
- Significant kidney disease (creatinine higher than 1.8 mg/dl)
- Significant liver disease (Bilirubin > 20 mmoll/L)
- Significant lung disease (FEV1 < 1.5 L, pO2 < 70 in room air, pCO2 > 45)
- Psychiatric illness requiring hospital admission
- Warfarin intake
- Digoxin intake
- Pregnancy
- Breast feeding
- Inability to have follow/up