Inclusion Criteria1. Both genders and ages 20 through 65 (subjects are at least 20 years old but not yet 66).
2. Clinical diagnosis of ischemic stroke, causing a measurable neurological deficit.
3. Onset of symptoms of ischemic stroke within 10 days of initiation of treatment with the study drug.
4. Patients have a total National Institutes of Health Stroke Scale (NIHSS) between 8 and 22 inclusive by the time of randomization.
5. Patients have a total Barth Index (BI) less than 60 or Modified Rankin Scale (MRS) at least 3 by the time of randomization.
6. No previous history of stroke or previous stroke with Modified Rankin Scale < 1.
7. Patient must have a CT or MRI examination compatible with the clinical diagnosis of acute ischemic stroke.
8. Signed informed consent from patient or legally authorized representative.
Exclusion Criteria1. Patient has only major symptoms that are rapidly improving by the time of randomization.
2. History of stroke within the previous 3 months, exclude TIA.
3. Patient has a CT or MRI scan with evidence of a non-ischemic mechanism, subarachnoid hemorrhage, primary intracerebral or intraventricular hemorrhage.
4. Patients with known or suspected prior intracranial haemorrhage or history of brain injury or brain tumor.
5. Patient had documented history of any atrial fibrillation occurring 6 months before randomization.
6. Hypertension, defined as systolic blood pressure > 185 mmHg or diastolic blood pressure >110 mmHg or requiring aggressive (eg, intravenous antihypertensive) treatment to reduce blood pressure to within these limits.
7. Recurrent peptic ulcer or gastrointestinal bleeding documented by radiographic or endoscopic means within the past 3 months.
8. Pregnant or lactating women or women of childbearing potential who are not practicing reliable birth control.
9. Platelet count less than 100,000 cells/ml.
10. Activated partial thromboplastin time (aPTT) prolongation greater than 2 seconds above the upper limit of normal for local laboratory.
11. International normalized ratio (INR) greater than or equal to 1.4.
12. Uncontrolled hyperglycemia (Sugar AC > 200 mg/dl).
13. History of alcohol or drug abuse in the previous 3 months.
14. History of hypersensitivity or intolerance of study drug or aspirin.
15. Neurological (other than the presenting stroke) or psychiatric conditions that may affect the patient's functional status and/or that may interfere with the patient's assessment.
16. Previously in the BRAIN-Study or participation in a research protocol for investigation of a pharmaceutical agent or innovative invasive procedure within the past 30 days.
17. Any other known clinically significant medical disorder (e.g., a severe comorbid disease or dementia, transient cerebral ischemia, lower gastrointestinal bleeding, bleeding diathesis, hepatorenal diseases, cancer, and AIDS).
18. Patients who have received anticoagulant agents, antiplatelet agents (except Aspirin), thrombolytics with 48-hour before randomization.