Efficacy and Safety of Young Health Plasma on Acute Stroke

Not yet recruiting

Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- Age 65-80 years
- Clinical presentation of spontaneous intracerebral hemorrhage/ischemic stroke
- CT/MRI/MRA scan compatible with spontaneous intracerebral hemorrhage/ ischemic stroke
- Time to young plasma treatment < 72 h from symptom onset
- Glasgow Coma Score > 6 on initial presentation or improvement to a Glasgow Coma Score > 6 within the time frame for enrollment
- The first-ever primary supratentorial intracerebral basal ganglia hemorrhage 5-30ml
- Signed and dated informed consent is obtained
- TOAST: Large-artery atherosclerosis

Exclusion Criteria

- Patients who will undergo surgical evacuation of intracerebral hemorrhage/ischemic stroke
- Inability to undergo neuroimaging with Magnetic Resonance
- Glasgow Coma Score < 6
- Significant past history of disability, modified Rankin Scale(mRS)≥1
- Primary intraventricular hemorrhage ICH due to coagulopathy (PT > 15 s or International Normalized Ratio > 1.3, Partial Thromboplastin Time > 36) or trauma
- Thrombocytopenia: platelet count <100 000
- Clinically significant hepatic disease as demonstrated by history, clinical exam (ascites, varices), or laboratory findings (LFTs >2x normal, coagulopathy as described)
- Comorbid conditions likely to complicate therapy including but not limited to the following: a history of New York Heart Association class II, III, or IV Congestive Heart Failure; end-stage acquired immune deficiency syndrome
- Known pregnancy, or positive pregnancy test, or breast feeding
- Malignancy (history of or active)
- Bradyarrhythmia and Atrioventricular Block
- Concomitant use with antineoplastic,immunosuppressive or immune modulating therapies
- Macular Edema
- Life expectancy of less than 90 days due to comorbid conditions
- Occurrences of secondary intracerebral hemorrhage/ischemic stroke
- Patients known or suspected of not being able to comply with the study protocol due to alcoholism, drug dependency, noncompliance, living in another state or any other cause