Efficacy and Safety of MRI-based Thrombolysis in Wake-up Stroke "WAKE-UP"

Active, not recruiting

Phase 3 Results N/A

Summary of Purpose

WAKE-UP is an investigator initiated European multicenter randomized controlled clinical trial of MRI based thrombolysis in acute stroke patients with unknown time of symptom onset, e.g. due to recognition of stroke symptoms on awakening. Objective of WAKE-UP is to prove efficacy and safety of MRI-based intravenous thrombolysis with Alteplase in patients waking up with stroke symptoms or patients with otherwise...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 18 July 2017.

1 Sep 2012 30 Jan 2012 1 Mar 2018 1 May 2018 1 Jul 2017 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics




Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Investigator)
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment


  • Christian Gerloff, MD

    gerloff@uke.de +49 40 7410

  • Goetz Thomalla, MD

  • Goetz Thomalla, MD,PhD