This study was designed in order to evaluate and compare the efficacy and safety between aspirin and clopidogrel in the patient with low stroke risk Atrial Fibrillation (AF).
Efficacy outcome will be evaluated the major cerebro-cardiovascular event including stroke, cardiovascular death, and myocardial infarction during 1 year-medication period. In addition, safety outcome will be evaluated the gastrointestinal responses including peptic ulcer and upper gastrointestinal bleeding events to both study drugs by repeated gastroenteroscopic examinations before and after medication by GI specialist.
- Clopidogrel (Plavix®)Drug
Other Names: Plavix ARM 1: Kind: Experimental Label: Intervention: Clopidogrel Description: Case management with clopidogrel 75mg once daily is provided for stroke prevention in AF patient.
- Aspirin Drug
Other Names: Aspirin at bedtime ARM 1: Kind: Experimental Label: Control: Aspirin Description: Usual care with aspirin 100mg once daily is provided for stroke prevention in AF patient.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Major Cerebrovascular and cardiac events including stroke, CV death, MI||1 year after randomization|
|Primary||Major gastrointestinal event including peptic ulcer disease and bleeding||1 year after randomization|