Effects of rTMS and tDCS on Motor Function in Stroke

Completed

Phase N/A Results N/A

Update History

26 Apr '17
Trial was updated to "N/A."
The gender criteria for eligibility was updated to "All."
20 Apr '16
The eligibility criteria were updated.
New
Inclusion criteria: (1) All subjects must be between the ages of 18-90. Exclusion criteria: 1. History of Major depression, as defined by Beck Depression scale 30; 2. Any substantial decrease in alertness, language comprehension, or attention that might interfere with understanding instructions for motor testing; 3. Contraindications to TMS - history of seizures - unexplained loss of consciousness - metal in the head - frequent or severe headaches or neck pain - implanted brain medical devices. 4. Contraindications to tDCS - metal in the head - implanted brain medical devices 5. Advanced liver, kidney, cardiac, or pulmonary disease; 6. A terminal medical diagnosis consistent with survival < 1 year; 7. Coexistent major neurological or psychiatric disease (to decrease number of confounders); 8. A history of significant alcohol or drug abuse in the prior 6 months; 9. Subjects may not be actively enrolled in a separate intervention study targeting stroke recovery and any other clinical trials; 10. Subjects with global aphasia and deficits of comprehension 11. Pregnancy. Female subjects of child bearing potential will be asked to take a pregnancy test. If the pregnancy test is positive, the subject may not enroll in the study. 12. Use of neuropsychotropic medications [healthy subjects only] Additional inclusion criteria for stroke subjects: 1. First-time clinical ischemic or hemorrhagic cerebrovascular events - evidenced by a radiological (or physician's) report 2. Weakness, defined as score of less than 55 (out of 66) on arm motor Fugl-Meyer (FM) scale 3. Stroke onset >6 months prior to study enrollment . Additional exclusion criteria for stroke subjects: 1. Subjects may not have already received TMS and/or tDCS stimulation for stroke; 2. History of epilepsy before stroke or episodes of seizures within the last six months;
Old
Inclusion criteria: (1) All subjects must be between the ages of 18-90. Exclusion criteria: 1. History of Major depression, as defined by Beck Depression scale 30; 2. Any substantial decrease in alertness, language comprehension, or attention that might interfere with understanding instructions for motor testing; 3. Contraindications to TMS - history of seizures - unexplained loss of consciousness - metal in the head - frequent or severe headaches or neck pain - implanted brain medical devices. 4. Contraindications to tDCS - metal in the head - implanted brain medical devices 5. Advanced liver, kidney, cardiac, or pulmonary disease; 6. A terminal medical diagnosis consistent with survival < 1 year; 7. Coexistent major neurological or psychiatric disease (to decrease number of confounders); 8. A history of significant alcohol or drug abuse in the prior 6 months; 9. Subjects may not be actively enrolled in a separate intervention study targeting stroke recovery and any other clinical trials; 10. Subjects with global aphasia and deficits of comprehension 11. Pregnancy. Female subjects of child bearing potential will be asked to take a pregnancy test. If the pregnancy test is positive, the subject may not enroll in the study. 12. Use of neuropsychotropic medications [healthy subjects only] Additional inclusion criteria for stroke subjects: 1. First-time clinical ischemic or hemorrhagic cerebrovascular events - evidenced by a radiological (or physician's) report 2. Weakness, defined as score of less than 55 (out of 66) on arm motor Fugl-Meyer (FM) scale 3. Stroke onset >6 months prior to study enrollment . Additional exclusion criteria for stroke subjects: 1. Subjects may not have already received TMS and/or tDCS stimulation for stroke; 2. History of epilepsy before stroke or episodes of seizures within the last six months;
16 Apr '14
A location was updated in Boston.
New
The overall status was removed for Spaulding Rehabilitation Hospital.