Effects of Exercise on Endothelial Function in Stroke Patients

Active, not recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Ischemic Stroke greater than 6 months prior in men or women ages 40-85
- Residual hemiparetic gait deficits
- Already completed all conventional inpatient and outpatient physical therapy
- Adequate language and neurocognitive function to participate in exercise testing and training

Exclusion Criteria

- Already performing greater than 20 minutes aerobic exercise 3 times per week
- All insulin dependent diabetics; non-insulin dependent diabetics with fasting glucose greater than 180 mg/dl
- Alcohol consumption greater than 2oz. liquor or equivalent per day
- Cardiac history of: (a) unstable angina, (b) recent (less than 3 months) myocardial infarction, (c) symptomatic congestive heart failure, (d) hemodynamically significant valvular dysfunction
- Medical History of: (a) recent (less than 3 months) hospitalization for severe medical disease, (b) PAOD (Peripheral Arterial Obstructive Disease) with claudication, (c) orthopedic or chronic pain condition restricting exercise, (d) pulmonary or renal failure, (e) active cancer, (f) poorly controlled hypertension (greater than 160/100) (g) Anemia defined by hematocrit less than 30
- Neurological History of: (a) dementia with Mini-Mental Status Score less than 23 (less than 17 if education level at or below 8th grade), and diagnostic confirmation by neurologist or geropsychiatrist, (b) severe receptive or global aphasia which confounds testing and training, operationally defined as unable to follow 2 point commands, (c) hemiparetic gait from prior stroke preceding the index stroke defining eligibility, (d) non-stroke neurological disorder restricting exercise (e.g. Parkinson's Syndrome), (e) untreated major depression
- Pregnancy