Effects of Epidurally Administered Ropivacaine Concentration on the Hemodynamic Parameters "PNU"

Completed

Phase 4 Results N/A

Trial Description

In this trial, the investigators intend to examine whether the concentration of local anesthetics during epidural analgesia could be modulating factor for change of hemodynamics in patients undergoing major upper abdominal surgery.

Detailed Description

One hundred and twenty patients scheduled for major abdominal surgery under TEA combined general anesthesia were randomized in a double-blinded method to receive one of three different concentration study solutions in 8 ml of volume after the induction of anesthesia: 0.75% ropivacaine (60 mg), 0.375% ropivacaine (30 mg), or 0.2% ropivacane (16 mg).
In each group, the patients were divided into two subgroups at the age of 60 to perform age based analysis. The acquired hemodynamic data after administration of epidural loading dose were compared and analyzed between young and elderly groups in each group.

Conditions

Interventions

  • 0.75% ropivacaine concentration Drug
    Intervention Desc: 0.75% ropivacaine 8ml was injected epidurally after induction of general anesthesia
    ARM 1: Kind: Experimental
    Label: 0.75% ropivacaine
    Description: 0.75% ropivacaine 8ml was injected epidurally after induction of general anesthesia
  • 0.375% ropivacaine concentration Drug
    Intervention Desc: 0.375% ropivacaine 8ml was injected epidurally after induction of general anesthesia
    ARM 1: Kind: Experimental
    Label: 0.375% ropivacaine
    Description: 0.375% ropivacaine 8ml was injected epidurally after induction of general anesthesia
  • 0.2% ropivacaine concentration Drug
    Intervention Desc: 0.2% ropivacaine 8ml was injected epidurally after induction of general anesthesia
    ARM 1: Kind: Experimental
    Label: 0.2% ropivacaine
    Description: 0.2% ropivacaine 8ml was injected epidurally after induction of general anesthesia

Outcomes

Type Measure Time Frame Safety Issue
Primary hemodynamic changes depends on the concentration of ropivacaine during 1hour after administration of epidural drug dosing
Secondary Age based hemodynamic changes depends on the concentration of ropivacaine during 1hour after administration of epidural drug dosing

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