Effects of Donepezil on Regional Cerebral Blood Flow Following Aneurysmal Subarachnoid Haemorrhage "DASH"


Phase 2 Results N/A

Eligibility Criteria

Inclusion Criteria

- age 18 - 85 years
- Fisher score 2-4
- recruitment within 12 - 72 hours of hemorrhage

Exclusion Criteria

- pregnancy
- breast feeding
- allergy to donepezil or other piperidine derivatives
- participants unwilling to use appropriate birth control up to 6 weeks after enrolment
- known dementia
- severe liver failure (Child-Pugh C)
- sick sinus syndrome or other supraventricular cardiac conduction abnormalities
- inspired oxygen requirement greater than 60%
- history of brittle asthma or obstructive airway disease
- aneurysm unsuitable for endovascular coiling
- concomitant use of cholinesterase inhibitor (e.g. rivastigmine, galantamine, etc)