Effects of Deep Brain Stimulation of the Dentate Nucleus on Cerebellar Ataxia


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

1. Patients with diagnosis of chronic cerebellar ataxia (> 6 months);
2. Age ≥18 years;
3. Be able to understand study protocol;
4. Signed, written informed consent (approved by the Institutional Ethics Committee) obtained prior to any study procedure;
5. Refractory symptoms response to first, second and third line pharmacological treatment;
6. Daily living activities impaired because the ataxia;
7. Be able to undergo surgery procedures.

Exclusion Criteria

1. Abuse of alcohol, drugs
2. Known psychiatric conditions
3. Contraindications to DBS
4. Heart failure or cardiac disease that contraindicates surgery procedures;
5. Pacemaker or other stimulators implanted active;
6. Positive blood ß-HCG test for women;
7. Other medical conditions demand hospitalization; Participation in other clinical studies at the same time;