Effect of Tadalafil on Cerebral Large Arteries in Stroke "ETLAS"


Phase 2 Results N/A

Summary of Purpose

In a double blind placebo-controlled cross-over study the effect of tadalafil on blood flow velocity in the large arteries of the brain, cortical brain oxygenation, peripheral endothelial function, and endothelial biomarkers will be tested in patients with lacunar stroke caused by cerebral small vessel disease.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 20 August 2017.

29 Nov 2016 7 Jun 2016 4 Aug 2017 4 Aug 2017 1 Aug 2017 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics




Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Pharmacodynamics Study
  • Intervention: Crossover Assignment