Effect of Repeated Botulinum Toxin Injection on Gait Pattern in Stroke Patients "TRITITOX"


Phase N/A Results N/A

Trial Description

Chronic stroke patients exhibit gait pattern alterations which are mainly due to spasticity and treated with repetitive multifocal botulinum toxin injection(BTI). Several studies demonstrated that single BTI-session in a single muscle of paretic lower limb(LL) improved kinematic gait parameters(GP) but surprisingly none of them assessed the effects of repetitive multifocal BTI on patient's gait pattern and their duration.
The aim was to evaluate the impact of repetitive multifocal BTI-sessions on GP of chronic stroke patients. To that end, gait of patients will be compared using 3D-gait analysis after 3 consecutives BTI sessions.

Detailed Description

All the patients will be treated with BTI . These injections will be performed under electrical stimulation control (~5mA). The dose, the number of site of injection per muscle is at the discretion of the physician according to patients' needs and physicians' routine clinical practice. The dilution the most commonly used will be 100 U for 2.5ml (XEOMIN®)



  • Motion analysis Other
    Intervention Desc: Motion analysis is used to assess the modifications of gait pattern in chronic spastic stroke patients regularly treated with botulinum toxin injection
    ARM 1: Kind: Experimental
    Label: Chronic spastic stroke patients
    Description: Chronic spastic stroke patients treated regularly with botulinum toxin injection in lower limb muscles

Trial Design

  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population



Type Measure Time Frame Safety Issue
Primary kinematics gait parameters 3h No
Secondary spatiotemporal gait parmeters 3h No
Secondary spatiotemporal gait parameters 3h No