Effect of Nimodipine on Regional Cerebral Glucose Metabolism in Patients with Acute Ischemic Stroke as Measured by Positron Emission Tomography.

Completed

Phase N/A Results

Trial Description

To assess the differences in permanent morphologic and functional damage between nimodipine and placebo-treated stroke patients.

Interventions

  • Nimodipine (NimotopĀ®)Drug
    Intervention Desc: Calcium channel blocker (L-type calcium channels)

Trial Design

Randomized, double-blind, placebo-controlled study of 27 patients.

Patient Involvement

Patients were randomized to receive intravenous nimodipine, 1 mg/hr in first 2 hours, 2 mg/hr next 5 days, followed by 30 mg oral qid. day 6-21 or an identical regimen of placebo. All patients were treated with low molecular weight dextran (500 ml/day for 15 days) and glycerol (10% for 5 days).

Outcomes

Type Measure Time Frame Safety Issue
Primary Mathew Score on admission and at 3 weeks, Barthel Index at 21 days and 6 months, FDG PET on the day of admission and at 21 days.