Effect of Hypervolemic Hemodilution of Regional Cerebral Blood Flow in Patients with Acute Ischemic Stroke


Phase 2 Results

Trial Description

To study the effect of hypervolemic hemodilution on cerebral blood flow (CBF).


Trial Design

Open, randomized, controlled trial of 27 patients.

Patient Involvement

12 patients were randomly allocated as controls without 10% hydroxyethylstarch (HES) infusion and 15 received 500 ml HES daily, infused over a period of 5-7 h, for 7 days.


Type Measure Time Frame Safety Issue
Primary CBF was measured on days 1, 2 and 7 by the xenon 133 inhalation method.


Alexander-von-Humboldt Foundation, FRG