Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery


Phase N/A Results N/A

Summary of Purpose

In patients undergoing craniotomy, 0.9% normal saline is commonly administered in order to reduce cerebral edema. Excessive administration of 0.9% normal saline has been to reported to cause hyperchloremic metabolic acidosis. On the other hand, hypovolemia due to insufficient fluid replacement for perioperative loss can also result in metabolic acidosis by lactic acid accumulation. However, the guideline for...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 26 January 2015.

1 Dec 2012 18 Nov 2012 1 Jun 2014 1 Jul 2014 1 Jan 2015 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics




Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Outcomes Assessor)
  • Purpose: Supportive Care
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment