Effect of Ezetimibe Plus Simvastatin Versus Simvastatin Alone on Atherosclerosis in the Carotid Artery (ENHANCE)(P02578) "ENHANCE"


Phase 3 Results

Summary of Purpose

The purpose of the study is to determine whether ezetimibe plus simvastatin will be more effective than simvastatin alone in preventing progression of atherosclerosis of the inner layer of the carotid artery.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 10 May 2017.

1 Jun 2002 31 Oct 2007 25 Apr 2006 25 Apr 2006 1 May 2017 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
  • Purpose: Prevention
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment


  • Enrico P. Veltri, MD Schering-Plough