Effect of Acupuncture Intervention on Improving Neurological Function and Antiinflammation in Patients With Acute Ischemic Stroke "ANAIS"

Recruiting

Phase N/A Results N/A

Trial Description

This study will have acupuncture intervention in acute ischemic stroke patients and evaluate the effect in neurological function improving by National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS), Barthel Index, and antiinflammatory actions by biomarkers.

Detailed Description

Acupuncture Treatment in Stroke is a widely practiced in Taiwan, mainland China, and around the world. The using in stroke group is countless. Numerous clinical trials have been conducted in the medical community to assess efficacy, and the results mostly suggest that acupuncture may be an effective, low side effects adjuvant therapy. Ischemic stroke is also associated with chronic inflammation-related diseases. In recent years, the anti-inflammatory effect of acupuncture was gradually found. So, whether in the basic or in clinical, the investigators can deduce that acupuncture may be helpful for stroke as an adjuvant therapy.
This study evaluates the neurological function of patients with acute stroke by using the widely used National Institutes of Health Stroke Scale (NIHSS), Modified Rankin Scale (mRS) and Barthel Index. Also, the investigators assess the degree of inflammation by biomarkers. Therefore, the purpose of this study is to explore the effect of acupuncture intervention on acute ischemic patients and its relationship in anti-inflammatory actions.

Conditions

Interventions

  • Traditional Acupuncture Other
    Intervention Desc: widely ongoing traditional acupoints in scalp and limbs with traditional "deqi" manipulation, for stroke patient
    ARM 1: Kind: Experimental
    Label: Traditional Acupuncture
    Description: Traditional acupoints and traditional "deqi" manipulation
  • Minimal Acupuncture Procedure
    Intervention Desc: non-traditional acupoints in scalp and limbs, with minimal manipulation
    ARM 1: Kind: Experimental
    Label: Minimal Acupuncture
    Description: To avoid traditional acupoints and minimal manipulation

Outcomes

Type Measure Time Frame Safety Issue
Primary National Institutes of Health Stroke Scale (NIHSS) 1.beginning of stroke (within 3 days after onset); 2.after a 4-weeks acupuncture course (within 7 days after last acupuncture); 3. a month later after acupuncture course (about 28±7 days after last acupuncture)
Secondary modified Rankin Scale (mRS) 1.beginning of stroke (within 3 days after onset); 2.after a 4-weeks acupuncture course (within 7 days after last acupuncture); 3. a month later after acupuncture course (about 28±7 days after last acupuncture)
Secondary Barthel Index 1.beginning of stroke (within 3 days after onset); 2.after a 4-weeks acupuncture course (within 7 days after last acupuncture); 3. a month later after acupuncture course (about 28±7 days after last acupuncture)
Secondary inflammatory biomarkers 1.beginning of stroke (within 3 days after onset); 2.after a 4-weeks acupuncture course (within 7 days after last acupuncture); 3. a month later after acupuncture course (about 28±7 days after last acupuncture)

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