Echoplanar Imaging Thrombolysis Evaluation Trial (EPITHET)


Phase 2 Results

Eligibility Criteria

Inclusion Criteria

- Patients who present:
- with acute hemispheric stroke within 3-6 hours of onset,
- have at least moderate limb weakness,
- a National Institute of Health Stroke Scale (NIHSS) score > 4,
- had a pre-stroke modified Rankin Scale (MRS) score of 0 - 2
- and who are able to undergo CT and MRI, are eligible for this study.

Exclusion Criteria

- Females who are pregnant or breast-feeding,
- persons who have CT-verified hemorrhagic stroke, major ischemia ( > 33% of the middle cerebral artery (MCA) territory infarcted), subarachnoid hemorrhage, arteriovenous malformation, aneurysm, intracranial neoplasm that is terminal or poses a risk of hemorrhage ,
- are comatose or severely obtunded with fixed eye deviation and complete hemiplegia,
- have had another stroke within the past 6 weeks,
- have had a seizure prior to the administration of the study drug,
- have active peptic ulceration, bleeding diatheses, previous intracerebral hemorrhage,
- blood pressure > 185/110,
- major surgery or trauma within the past 30 days, or any other contraindications to tPA
- have a presumed septic embolus or a myocardial infarction within the past 30 days
- blood glucose values are < 2.8 or > 22.0 mmol/L,
- pacemakers, aneurysm clips, implanted devices, claustrophobia, or any other contraindications to MRI,
- decreased consciousness,
- rapid clinical improvement,
- confounding neurological condition (e.g. dementia),
- any other life-threatening illness, or who are participating in another clinical trial, will be excluded from this study.