Echoplanar Imaging Thrombolysis Evaluation - Pilot Study "EPITHET - Pilot"


Phase N/A Results

Eligibility Criteria

Inclusion Criteria

Patients who present with acute hemispheric stroke within 3-6 hours of onset, who have at least moderate limb weakness, a National Institute of Health Stroke Scale (NIHSS) score > 4, who had a pre-stroke modified Rankin Scale (MRS) score of 0 or 1, and who are able to undergo CT and MRI, are eligible for this study.

Exclusion Criteria

Females who are pregnant or breast-feeding, and persons who have CT-verified hemorrhagic stroke, major ischemia ( > 33% of the middle cerebral artery (MCA) territory infarcted), subarachniod hemorrhage, arteriovenous malformation, aneurysm, intracranial neoplasm that is terminal or poses a risk of hemorrhage , who are comatose or severely obtunded with fixed eye deviation and complete hemiplegia, who have had another stroke within the past 6 weeks, who have had a seizure prior to the administration of the study drug, who have active peptic ulceration, bleeding diatheses, previous intracerebral hemorrhage, blood pressure > 185/110, major surgery or trauma within the past 30 days, or any other contraindications to tPA, who have a presumed septic embolus or a myocardial infarction within the past 30 days, whose blood glucose values are < 2.8 or > 22.0 mmol/L, who have pacemakers, aneurysm clips, implanted devices, claustrophobia, or any other contraindications to MRI, who have decreased consciousness, rapid clinical improvement, a confounding neurological condition (e.g. dementia), or any other life-threatening illness, or who are participating in another clinical trial, will be excluded from this study.