Early Sleep Apnea Treatment in Stroke "eSATIS"

Recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Informed consent as documented by signature
- Admission to one of the participating centers
- Age 18-85 years
- Ischemic stroke detectable by neuroimaging, affecting internal carotid artery, anterior cerebral artery (ACA), middle cerebral artery (MCA), posterior cerebral artery (PCA) and/or branches thereof
- Symptom onset to admission < 24 hours
- AHI > 20/h or < 5/h
Exclusion Criteria
- Primary hemorrhagic stroke
- Secondary parenchymal haemorrhage (PH 1 and PH 2 according to ECASS; secondary haemorrhagic infarction HI 1 and HI 2 can be included)
- Small strokes (diameter < 1.5cm)
- Coma/Stupor
- Intubation
- Clinically unstable or life threatening condition (oxygen-dependent pulmonary disease or severe pulmonary complications, severe renal or liver insufficiency, agitated patient, patients under blood pressure-elevating substances >24h after stroke, patients that need decompressive carniectomy )
- Heart failure defined as known congestive heart failure (CHF) functional class NYHA III-IV (New York Heart Association) OR CHF NYHA II and hospitalization caused by CHF in the preceding 24 months
- OR left ventricular ejection fraction lower or equal 45% either known from preceding imaging method or found at the routine examination (echocardiography) during hospitalization
- Oxygen supply > 2 l/min during day and night
- Intermediate AHI value: ≥ 5/h and ≤ 20/h
- Known progressive neurological diseases (such as dementia, Parkinson's disease or multiple sclerosis)
- Drug or alcohol abuse (>14 units alcohol / week for males, >7 units alcohol / week for females)
- Inability to follow study procedure
- Pregnancy
- Any given contraindications to MRI or MRI-contrast agent (allergy or severe renal impairment)
- Any given contraindications to ASV treatment