Early intervention with nimodipine in subarachnoid hemorrhage


Phase N/A Results

Trial Description

To determine the effect of early intervention with nimodipine on blood pressure (BP), cerebral blood flow (CBF), and clinical outcome in patients with subarachnoid hemorrhage.


  • Nimodipine (NimotopĀ®)Drug
    Other Names: The treatment group
    Intervention Desc: Calcium channel blocker (L-type calcium channels)

Trial Design

Randomized, double-blind, placebo-controlled trial of 50 patients at a single center.

Patient Involvement

Patients were randomized to receive oral nimodipine 60mg, or placebo. Patients who underwent surgery for clipping of a cerebral aneurysm received 200 mg nimodipine or placebo instilled into the basal cisterns intraoperatively. Therapy was continued for 21 days.


Type Measure Time Frame Safety Issue
Primary Clinical outcome at 3 months, changes in CBF and/or BP.