To determine the effect of early intervention with nimodipine on blood pressure (BP), cerebral blood flow (CBF), and clinical outcome in patients with subarachnoid hemorrhage.
- Nimodipine (Nimotop®)Drug
Intervention Desc: Calcium channel blocker (L-type calcium channels)
Randomized, double-blind, placebo-controlled trial of 50 patients at a single center.
Patients were randomized to receive oral nimodipine 60mg, or placebo. Patients who underwent surgery for clipping of a cerebral aneurysm received 200 mg nimodipine or placebo instilled into the basal cisterns intraoperatively. Therapy was continued for 21 days.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Clinical outcome at 3 months, changes in CBF and/or BP.|