Early Detection of Arteriosclerosis

Active, not recruiting

Phase N/A Results N/A

Trial Description

Arteriosclerosis is a common chronic disease with well known risk factors like diabetes mellitus, hypertension, dyslipidemia, adipositas and smoking, leading to severe complications like myocardial infarction, stroke or peripheral arterial occlusive disease. In addition to life-style factors there is also a genetic predisposition to develop complicated atherosclerosis.
Objective: Improve individual risk prediction by clinical phenotyping and genotyping.

Detailed Description

About 300 patients who are treated for various conditions at the department of general medicine at our hospital will be included prospectively in the study. This observational cohort will be followed for at least 10 years follow-up examinations.
At baseline and during follow up visits detailed clinical phenotyping is planned (medical and family history,standardized clinical and physical examinations, lab, RX, ECG, stress-test or echocardiogram). The genotyping is performed by DNA-isolation from leucocytes collected at baseline.

Conditions

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Probability Sample

Trial Population

teaching hospital primary care clinic

Outcomes

Type Measure Time Frame Safety Issue
Primary Cardiovascular events 10 years at least No
Secondary Disease activity score 2 / 5 / 10 years No

Biospecimen Retention:Samples With DNA - Whole blood / serum / white cells / plasma

Sponsors