To compare effects of atenolol vs placebo, and two doses of aspirin for stroke prevention.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Atenolol (Tenormin)Drug
Other Names: tenormin Intervention Desc: Beta-adrenergic receptor antagonist (beta-blocker); anti-hypertensive
Double-blind, randomized, controlled, multicenter clinical trial.
Two different therapeutic comparisons were made by double randomization: 30 mg vs. 300 mg acetylsalicylic acid, and 50 mg atenolol vs. placebo.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Death from all vascular causes, nonfatal stroke, or nonfatal myocardial infarction.|
|Secondary||Disability measured by Rankin scale. Bleeding complications.|