Dutch TIA Study "Dutch TIA"


Phase N/A Results

Trial Description

To compare effects of atenolol vs placebo, and two doses of aspirin for stroke prevention.


  • Aspirin (stroke prevention) Drug
    Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
  • Atenolol (Tenormin)Drug
    Other Names: tenormin
    Intervention Desc: Beta-adrenergic receptor antagonist (beta-blocker); anti-hypertensive

Trial Design

Double-blind, randomized, controlled, multicenter clinical trial.

Patient Involvement

Two different therapeutic comparisons were made by double randomization: 30 mg vs. 300 mg acetylsalicylic acid, and 50 mg atenolol vs. placebo.


Type Measure Time Frame Safety Issue
Primary Death from all vascular causes, nonfatal stroke, or nonfatal myocardial infarction.
Secondary Disability measured by Rankin scale. Bleeding complications.